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Inglés > Español: Artículo cientifico sobre tecnologia farmaceuitica

articulo cientifico sobre tecnologia farmaceuitica.


Ejemplo de texto:
Novel interpenetrating polymer network (IPN) nanogels composed of poly(acrylic acid) and gelatin were
synthesised by one pot inverse miniemulsion (IME) technique. This is based on the concept of nanoreactor
and cross-checked from template polymerization technique. Acrylic acid (AA) monomer stabilized
around the gelatin macromolecules in each droplet was polymerized using ammonium persulfate (APS)
and tetramethyl ethylene diamine (TEMED) in 1:5 molar ratio and cross-linked with N,N-methylene
bisacrylamide (BIS) to form semi-IPN (sIPN) nanogels, which were sequentially cross-linked using glutaraldehyde
(Glu) to form IPNs. Span 20, an FDA approved surfactant was employed for the formation of
homopolymer, sIPN and IPN nanogels. Formation of stable gelatin–AA droplets were observed at 2% surfactant
concentration. Dynamic light scattering (DLS) and scanning electron microscopy (SEM) studies of
purified nanogels showed small, spherical IPN nanogels with an average diameter of 255 nm. In contrast,
sIPN prepared using the same method gave nanogels of larger size. Fourier-transform infrared (FT-IR)
spectroscopy, SEM, DLS, X-ray photoelectron spectroscopy (XPS) and zeta potential studies confirm the
interpenetration of the two networks. Leaching of free PAA chains in sIPN upon dialysis against distilled
water leads to porous nanogels. The non-uniform surface of IPN nanogels seen in transmission electron
microscopy (TEM) images suggests the phase separation of two polymer networks. An increase of N/C
ratio from 0.07 to 0.17 (from PAA gel to IPN) and O/C ratio from 0.22 to 0.37 (from gelatin gel to IPN) of
the nanogels by XPS measurements showed that both polymer components at the nanogel surface are
interpenetrated. These nanogels have tailoring properties in order to use them as high potential drug
delivery vehicles for cancer targeting

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Sciences/Non-fiction books

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